Seeing Organizations as Biological Systems

There’s a continuing struggle between complexity and robustness in both evolution and human design. A kind of survival imperative, whether in biology, engineering, or business requires that simple, fragile systems become more robust. But the mechanisms to increase robustness will in turn make the system considerably more complex. Furthermore, that additional complexity brings with it its own unanticipated failure modes, which are corrected over time with additional robust mechanisms, which ...

 Heritable IQ is Boosted by Environment, Just Like Height

hough it’s not easy to pinpoint the causes of the rise in IQ scores, it’s no paradox that a heritable trait can be boosted by changes in the environment. That’s what happened with height, a trait that also is highly heritable and has increased over the decades, and for some of the same reasons: better nutrition and less disease. Brains are greedy organs, consuming about a fifth of the body’s energy, and they are made of fats and proteins that are demanding for the body to produce. Fig...

 Iron and Fever

Warm-blooded animals have an elaborate physiological control system to maintain a constant body temperature. In man, this temperature is about 37°C. Any significant deviation from this temperature puts stress on the body and makes it difficult to maintain metabolic processes at their normal rates. Why then, during sickness, should the temperature rise? It would seem that development of fever would cause things to go from bad to worse, and make it more difficult for the body to recuperate. Fe...

 Fever Reducing Medicines Increase the Spread of Infection

To put our lower bound for fp into perspective, consider that approximately 41 400 (95% CI: 27 100–55 700) deaths per year are attributed to seasonal influenza epidemics in the United States [43] (and an order of magnitude more worldwide [44]). Taken at face value, our results indicate, for example, that if Embedded Image then at least 700 deaths per year (95% CI: 30–2100) (and many more serious illnesses) could be prevented in the US alone by avoiding antipyretic medication for the treat...

 Autism as a Self-Fulfilling Prophecy

Diseases and other medical conditions can also have this self-fulfilling property. When medical conditions are widely discussed in the media, people are more likely to identify their symptoms, and doctors are more likely to diagnose (or misdiagnose) them. The best-known case of this in recent years is autism. If you compare the number of children who are diagnosed as autistic64 to the frequency with which the term autism has been used in American newspapers,65 you’ll find that there is an a...

 Metaphor for the Spread of Disease

To choose a rough example, think of a thorn which has stuck in a finger and produces an inflammation and suppuration. Should the thorn be discharged with the pus, then the finger of another individual may be pricked with it, and the disease may be produced a second time. In this case it would not be the disease, not even its product, that would be transmitted by the thorn, but rather the stimulus which engendered it. Now supposing that the thorn is capable of multiplying in the sick body, or ...